???????????????
????????????????????????????Public Citizen??29?????????????(Fluoroquinolone Antibiotics)??????????????????????????”Black-box”warnings?????????????FDA??????????
FDA should warn of tendon ruptures linked to Cipro, similar antibiotics
???Public Citizen Hot Issue 2006.8.29?
??http://www.citizen.org/hot_issues/issue.cfm?ID=1434
????????????1997?11???2005?12?31????FDA????????????FDA Adverse Event data?????????????????????????????????????(Tendon Rupture)262????(Tendinitis)258??????(Tendon Disorder (other))274??????????????794?????????
???????????????687?????????38.1%??????????????????61%?????????(????????????????????45%??????)????????????????(23%)??????????(8.8%)??????????????????????24.5%?????????????????????????????????????????????????????????????
??????????????????”Warninngs”???????????????????????????????????????????????????????????????????????????????????2005?5???????????????????
???????????????????????????????????????????????????????????????????????????????????????????????????????
?????
Fluoroquinolones and risk of Achilles tendon disorders: case-control study
?BMJ 2002;324:1306-1307?
??http://bmj.bmjjournals.com/cgi/content/full/324/7349/1306
Increased Risk of Achilles Tendon Rupture With Quinolone Antibacterial Use, Especially in Elderly Patients Taking Oral Corticosteroids
?Arch Intern Med. 2003;163:1801-1807?
??http://archinte.ama-assn.org/cgi/content/abstract/163/15/1801
???Group wants stronger antibiotics warnings
?????MSNBC 2006.8.29 AP?????
??????http://msnbc.msn.com/id/14574467