????????????
????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????The New England Journal of Medicine ????????????
Effectiveness of Atypical Antipsychotic Drugs in Patients with Alzheimer’s Disease
???NEJM 355:1525-1538?
??http://content.nejm.org/cgi/content/short/355/15/1525
????????????????????????????????421??????????????????????????????????????????????????????????????????
????????36?????82?????????????????????????????????????????????????????????????????
??????????????????????????????????????????????????24??????????16??????????18??????????????5???????????????
????????????????????????????22.1???????????26.7???????????????9.1?????????9.0????????????????
????12?????????????????????????????32%?????????26??????????29?????????21??????????????????????
???????????????????????????????????????????????????????????????????????
?FDA???2005?4??????????????????????????????????????????????????????????????1.6??1.7???????????????????????????????????????????????????????????????????????????????????????????????
?????
FDA Issues Public Health Advisory for Antipsychotic Drugs used for Treatment of Behavioral Disorders in Elderly Patients?FDA Talk Paper 2005.4.11?
??http://www.fda.gov/bbs/topics/ANSWERS/2005/ANS01350.html?
???Antipsychotic Medications Used to Treat Alzheimer�s Patients Found Lacking
????NIH News 2006.10.11?
???http://www.nih.gov/news/pr/oct2006/nimh-11.htm
Antipsychotic Drugs for Alzheimer’s??WebMD 2006.10.11?
???http://www.webmd.com/content/article/128/117082.htm
Study: Some Alzheimer’s Drugs Very Risky
?????Washington Post 2006.10.11?AP?????
? http://www.washingtonpost.com/wp-dyn/content/
article/2006/10/11/AR2006101101588.html
Little Benefit Seen in Antipsychotics Used in Alzheimer’s
?????Washington Post 2006.10.12?
http://www.washingtonpost.com/wp-dyn/content/
article/2006/10/11/AR2006101101595.html
???????????????????????????????? 58,861-864,2006?