???????????????
???TAKEDA?FDA?9?????????????????????????????????????????????????(Letter)?????????
Actos (pioglitazone) Tablets ACTOplus met (pioglitazone and metformin hydrochloride) Tablets Duetact (pioglitazone and glimepiride) Tablets
??http://www.fda.gov/medwatch/safety/2007/safety07.htm#Actos
??http://www.fda.gov/medwatch/safety/2007/Actosmar0807.pdf
????????????? ???????? Vol.5 No.6?????????????????
??http://www.nihs.go.jp/dig/sireport/weekly5/06070322.pdf
????????????????????????3.5???????????????????????????????????100????1.1?????????????????????100????1.9?????????????????
???????????????????????????????????????????????
????????????????????????????????
??????20???????? rosiglitazone?????Avandia???????????????????????????????????????????????
????????rosiglitazone ??metformin ??glyburide ???????????????????????????rosiglitazone???????????????????????????????????????????????
??????????????????????????????????????????????????????????????????
?FDA?????????????????????????????????????????????????????????????????
??????????? ???????? Vol.5 No.5??????????????
??????http://www.nihs.go.jp/dig/sireport/weekly5/05070308.pdf?
???????????? ??????????????????????Vol.5 No.11
??????http://www.nihs.go.jp/dig/sireport/weekly5/11070531.pdf
3?10??17:20???3?23??6?4??????