?????R?????????

?FDA?21????????????????????????????????Vytorin????????????????????????????????????Early Communication????????????????

Early Communication About an Ongoing Safety Review of Ezetimibe/Simvastatin (marketed as Vytorin), Simvastatin (marketed as Zocor) and Ezetimibe (marketed as Zetia) (FDA 2008.8.21)

?????????????? ???????? Vol.6 No.19 ?????????
????http://www.nihs.go.jp/dig/sireport/weekly6/19080918.pdf

??????????????????????????????????? FDA???????????????????????????????????????????????????????????????????????????FDA?WEB????????

??????????7???????Vytorin????????SEAS trial (Simvastatin and Ezetimibe in Aortic Stenosis)?????????????????????67?????Vytorin????106???????????????????????????????????????????????????????

SEAS???????????MEDICINE?BLOG?7?27??
?http://medicineblog.blog32.fc2.com/blog-entry-39.html

????????????????????????????????????
????????????8?4??
?http://intmed.exblog.jp/7366952/

Simvastatin and Ezetimibe in Aortic Stenosis (SEAS)
?American College of Cardiology?
?http://www.cardiosource.com/clinicaltrials/trial.asp?trialID=1721?

?FDA????9???????????????????????????????????Vytorin?????????????????????????????????????????????????????????????????????

?????????????????????????????????????????????????????????????????LDL-C??????????????????????????????LDL-C????????????????????????????????????

Statins, Low-Density Lipoprotein Cholesterol, and Risk of Cancer
(J Am Coll Cardiol, doi:10.1016/j.jacc.2008.06.037?Published online 20 August 2008)
?  http://content.onlinejacc.org/cgi/content/abstract/j.jacc.2008.06.037v1
??http://content.onlinejacc.org/cgi/content/full/j.jacc.2008.06.037v1

???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????

??????????ENHANCE??????????????????????????????????

?????TOPICS 2008.01.28??????????????????????

???
Cholesterol-Lowering Drugs Won’t Cause Cancer?Health Day 2008.8.20)
?http://www.healthday.com/Article.asp?AID=618601?

Statins Not Responsible for Increased Cancer Risk
??Medpage?TODAY 2008.8.20?
?http://www.medpagetoday.com/Cardiology/Dyslipidemia/tb/10615

FDA Says Vytorin Cancer Investigation Will Take Nine Months
??Medpage?TODAY 2008.8.21?
?http://www.medpagetoday.com/Cardiology/Dyslipidemia/tb/10633

9?22?????? 2009?12?24???????