????????LDL-C???????????????????
??????????????????????LDL-C??????????????????????????????????????????????LDL-C??????H?-CRP????C????????high-sensitivity C-reactive protein??????????????????????????????????????????????????????
Rosuvastatin to Prevent Vascular Events in Men and Women with Elevated C-Reactive Protein
??N Engl J Med 2008; 359: DOI: 10.1056/NEJMoa0807646?
?http://content.nejm.org/cgi/content/full/NEJMoa0807646
AHA: JUPITER Results Point to Role of Statins for ‘Apparently Healthy’ Patients
??Medpage TODAY 2008.11.9?
?http://www.medpagetoday.com/MeetingCoverage/AHA/11684
???????????????2008?11?10?
?http://www.astrazeneca.co.jp/activity/press/2008/08_11_10.html
??????????????????LDL-C?130????Hs-CRP??2.0mg/??????????????4.2mg/??????4.3mg/?????50????????60??????17,802??????66?????? 134/80???LDL-C?108???HDL-C?49???TG?118?T-C????186?????185?BMI??28.3??41%???????????????????????????????26??????? �JUPITER trial�?the Justification for the Use of Statins in Prevention:an Intervention Trial Evaluating Rosuvastatin???????????????????????????????????20??/????????????????6????????????????2008?3???????????????2010??11??????????????
????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????
???????1.9????LDL-C??50%???12????108?55????????Hs-CRP??37%?????2.2mg/?????????????54???????????48????????????????????47????????????????????????????????47????????????20??????????
???????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????????270??????216???????????????
???????????????????????????????????N Engl J Med ????????????????????????????????????????????????CRP????????????????????????????????????????????????????????????
????????????????2??????????????????????????????????????????????????????????????????????????????????????????
?Bloomberg??????????????????????????2009??????????????CRP??????????????????????????GE??????????????????1????3.45??????????????????????????????????????????????CRP???????????????????????????????????????????????????????????????????????
??????????????????????2005?5?
????http://www.yakugai.gr.jp/attention/index.php?year=2005
???
Statin Might Help More People Fight Heart Disease Than Thought
??HealthDay?2008.11.9?
??http://www.healthday.com/Article.asp?AID=621170
Study: Wider Cholesterol Drug Use May Save Lives
??ABC News 2008.11.9?AP???
??http://abcnews.go.com/Health/wireStory?id=6215432
Crestor, by Jove… or Not(ABC News 2008.11.10)
??http://abcnews.go.com/Health/HeartDiseaseNews/story?id=6207285
Heart Disease: Not About Cholesterol??Business Week 2008.4.15?
??http://www.businessweek.com/bwdaily/dnflash/content/apr2008/db20080414_688906.htm
??????????????????4?24???????????
??http://business.nikkeibp.co.jp/article/world/20080423/154034/
?????????? 2008?11?10?
Bloomberg 2008?11?10?
11?10??23?10??
N Engl J Med ????????????????26???????????????????????????????????????????????????????????????300?????????????????
The JUPITER Trial: Will You Change Your Practice??Clinilcal Directions?
?http://www.nejm.org/clinical%2Ddirections/jupiter%2Dstatins%2Dtrial/
???????????????????????hc-CRP??????????????????????????????????????????????????????????????????????????????
???????????????????????????
???????Hc-CRP???????????????????
????????????????????????????????????
?????????????????????????????????
?BMI?????????????????????????????????
?????study??????????????BMI???????????????
??????????????????????????????????
?1.9????????????????????????
?????????????????????????????????
????????????????????????????????????????????????????????????????????????????????
?????????????????????????????????????????????????????????????????????????????????????????????????????????????????
投稿者 by ???????? — 2008年11月12日(水)01:38
?????????3??LDL-C?????CRP??????????????????????65????????????????????????????43??????????? JUPITER trial ????????????????
?58????????(ACC)????????????
LDL-C?????CRP??????????????????????65???
????????JUPITER????
?????????????????
?http://www.astrazeneca.co.jp/activity/press/2009/09_04_02.html
????????????????????
Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial
?Lancet?2009; 373:1175-1182?
?http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(09)60447-5/abstract
A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism
??NEJM?Online First 2009.3.29)
?http://content.nejm.org/cgi/content/full/NEJMoa0900241v1
???CRP????????????NEJM ??????????????????????????????????????????????????????473????????????????????
?????
ACC: JUPITER Points to CRP as Independent Predictor of Outcome
?Medpage TODAY 2009.3.29?
? http://www.medpagetoday.com/MeetingCoverage/ACC/13484
投稿者 by ???????? — 2009年4月6日(月)09:58