??????????????????????????FDA?
??FDA?????10?????????????????????????????????????Early Communication?????????????????????????????????????????????????12?????????????????????
Update of Safety Review Follow-up to the October 1, 2007
Early Communication about the Ongoing Safety Review of Bisphosphonates
???FDA?2008.11.12?
?http://www.fda.gov/cder/drug/early_comm/bisphosphonates_update_200811.htm
??????????????Vol.6 No.26 ?????????
??http://www.nihs.go.jp/dig/sireport/weekly6/26081225.pdf
??????????NEJM ???????????????????????FDA??38,000?????19,687???????18,358????????????????????
?FDA???????????????????????????????????????????????????????????????????????????????????????????????????
????????????????????????????????????????????????????
?????TOPICS?2008.01.08????????????????
??Early Communication of an Ongoing Safety Review?FDA?
????http://www.fda.gov/cder/drug/early_comm/bisphosphonates.htm
?????????????????????Vol.5 No.21 ???
?????http://www.nihs.go.jp/dig/sireport/weekly5/21071018.pdf
??Alendronate and Atrial Fibrillation?NEJM 356: 1895-1896?
????http://content.nejm.org/cgi/content/extract/356/18/1895
????????????????????
??Information on Bisphosphonates?FDA 2008.1.7?
????http://www.fda.gov/cder/drug/infopage/bisphosphonates/default.htm
12?26??????