???????????????????????2???
???????????????Rosiglitazone??????????????????thiazolidinediones???????????????????????????????????????2007?11?????????????????????10????????????10??????????13,715???????2?????????????????????????31,769???????????????CMAJ ??Early release?????????
Long-term use of thiazolidinediones and fractures in type 2 diabetes: a meta-analysis
?CMAJ Early release, published Dec. 10, 2008?
???http://www.cmaj.ca/press/080486.pdf
???http://www.cmaj.ca/cgi/rapidpdf/cmaj.080486
?????????????????????2???????1???????????????????????????????????????????????????????????????????????
??????10???????????????thiazolidinediones??????????1.41?????????????????5?????????????????7,001????4,000?????????????????????????????????????????????????????2.23??????????
?????????????????????????2????????????????1.11??????1.24??????????????
???????????????????????????????????????thiazolidinediones?????????????????21??1??????????????????????????????????56?????????55??1?????????????????
?thiazolidinediones???????????????????????????????????????????????????????????????????????????????????????????????
??????????????????????????????????????????????????????????????????????????????????????????????????????????????
Thiazolidinediones: Do harms outweigh benefits?
?CMAJ Early release, published Dec. 10, 2008?
??http://www.cmaj.ca/cgi/rapidpdf/cmaj.081713
??????????????????????????????????????????????????????????????????????????????????????????????
?????TOPICS 2007.03.10????????????????
Diabetes drug pioglitazone (Actos): risk of fracture
??????CMAJ 2007; 177 (7).?
??http://www.cmaj.ca/cgi/content/full/177/7/723
???
Diabetes drugs ‘double bone risk’?BBC NEWS 2008.12.10?
??http://news.bbc.co.uk/1/hi/health/7771944.stm
Long-term use of diabetes drugs by women significantly increases risk of fractures?EurekAlert! 2008.12.10?
??http://www.eurekalert.org/pub_releases/2008-12/uoea-luo120808.php