?????????????????????
?????14??Merck ??Schering-Plough ??????ENHANCE????????preliminary results????????????????????????
?Merck/Schering-Plough Pharmaceuticals Provides Results of the ENHANCE Trial
???Schering-Plough News Release?2008.1.14?
??http://www.schering-plough.com/news/news_article.aspx?reqid=1095943
???ENHANCE?????????????????720?????????80mg???????????80mg??????10mg??????????????????�Vytorin�?????????????????????????????????????????????????????????????LDL-C????????????????????????????????????????????????????
???????????LDL-C?????????????????????????-??????intima-media thickness???????????????????????????????????LDL-C????????????????????????????????????
?Drugs Do Any Good? Research suggests that, except among high-risk heart patients, the benefits of statins such as Lipitor are overstated ?BuicessWeek 2008.1.17?
? http://www.businessweek.com/magazine/content/08_04/b4068052092994.htm
????? ???????????1?28????
??http://business.nikkeibp.co.jp/article/world/20080125/145406/
?????????????????????Vytorin????????Vytorin?Zetia?TV??????????????????????FDA?????????????6???????????????????Early Communication???????????????????????????
?FDA Issues Early Communication about an Ongoing Review of Vytorin
???FDA Statement 2008.1.25?
??http://www.fda.gov/bbs/topics/NEWS/2008/NEW01784.html
?Early Communication about an Ongoing Data Review for Ezetimibe/Simvastatin (marketed as Vytorin), Ezetimibe (marketed as Zetia), and Simvastatin (marketed as Zocor)
??http://www.fda.gov/cder/drug/early_comm/ezetimibe_simvastatin.htm
????????????? ??????????????????????Vol.6 No.4?????????
??http://www.nihs.go.jp/dig/sireport/weekly6/04080221.pdf
??????????????2006?11???????????????????????????????????????????????????????????????????????????????????????????3??????????????????????????????
??????
???Merck and Schering-Plough Respond To Issues Raised About ENHANCE Clinical Trial
?????Schering-Plough News Release?2008.1.25?
??????http://www.sgp.com/schering_plough/news/release.jsp?releaseID=1100091
???FDA and drug makers should have warned public earlier about Zetia, Vytorin
????????Public Citizen 2008.1.14?
??????http://www.citizen.org/hot_issues/issue.cfm?ID=1804
????Merck, Schering-Plough Defend Drug Study?AP?? 2008.1.25?
?http://ap.google.com/article/ALeqM5gG9N0uBoiAKFrDtmiSxpflszAlggD8UD7KO83
1?28??12:30???2?25??????
ENHANCE????????MEDICINE BLOG????????????
?http://medicineblog.blog32.fc2.com/blog-category-8.html
???N Engl J Med ?????????????????????????
Simvastatin with or without Ezetimibe in Familial Hypercholesterolemia
??N Engl J Med 2008;358:1431-1443.?
?http://content.nejm.org/cgi/content/full/358/14/1431
Correspondence
??N Engl J Med 2008; 359:529-533.)
?http://content.nejm.org/cgi/content/full/359/5/529
Does ENHANCE Diminish Confidence in Lowering LDL or in Ezetimibe?
??N Engl J Med 2008;358:1504-1507.??
?http://content.nejm.org/cgi/content/full/358/14/1504
Cholesterol Lowering and Ezetimibe
??N Engl J Med 2008;358:1507-1508.?
?http://content.nejm.org/cgi/content/full/358/14/1507
投稿者 by ???????? — 2008年8月25日(月)02:04